| Week 1 | Houston Texans vs. Indianapolis Colts | Sunday, September 8th, 2024 at 1:00pm ET |
| Week 2 | Indianapolis Colts vs. Green Bay Packers | Sunday, September 15th, 2024 at 1:00pm ET |
| Week 3 | Chicago Bears vs. Indianapolis Colts | Sunday, September 22nd, 2024 at 1:00pm ET |
| Week 4 | Pittsburgh Steelers vs. Indianapolis Colts | Sunday, September 29th, 2024 at 1:00pm ET |
| Week 5 | Indianapolis Colts vs. Jacksonville Jaguars | Sunday, October 6th, 2024 at 1:00pm ET |
| Week 6 | Indianapolis Colts vs. Tennessee Titans | Sunday, October 13th, 2024 at 1:00pm ET |
| Week 7 | Miami Dolphins vs. Indianapolis Colts | Sunday, October 20th, 2024 at 1:00pm ET |
| Week 8 | Indianapolis Colts vs. Houston Texans | Sunday, October 27th, 2024 at 1:00pm ET |
| Week 9 | Indianapolis Colts vs. Minnesota Vikings | Sunday, November 3rd, 2024 at 1:00pm ET |
| Week 10 | Buffalo Bills vs. Indianapolis Colts | Sunday, November 10th, 2024 at 1:00pm ET |
| Week 11 | Indianapolis Colts vs. New York Jets | Sunday, November 17th, 2024 at 8:20pm ET |
| Week 12 | Detroit Lions vs. Indianapolis Colts | Sunday, November 24th, 2024 at 1:00pm ET |
| Week 13 | Indianapolis Colts vs. New England Patriots | Sunday, December 1st, 2024 at 1:00pm ET |
| Week 14 | Bye Week | |
| Week 15 | Indianapolis Colts vs. Denver Broncos | Sunday, December 15th, 2024 at 4:25pm ET |
| Week 16 | Tennessee Titans vs. Indianapolis Colts | Sunday, December 22nd, 2024 at 1:00pm ET |
| Week 17 | Indianapolis Colts vs. New York Giants | Sunday, December 29th, 2024 at 1:00pm ET |
| Week 18 | Jacksonville Jaguars vs. Indianapolis Colts | Sunday, January 5th, 2025 at 1:00pm ET |
